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Abstract #2299

Application of Two-compartmental Pharmacokinetic Analysis with and without Vascular Term for Differentiating Benign and Malignant Spinal Tumors Measured by DCE-MRI

Ning Lang 1 , Hon J Yu 2 , Huishu Yuan 1 , and Min-Ying Su 2

1 Department of Radiology, Peking University Third Hospital, Beijing, China, 2 Tu&Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States

DCE-MRI was performed to differentiate 4 spinal lesions (9 myeloma, 85 metastatic cancer, 7 lymphoma, 24 benign tuberculosis). Two-compartmental pharmacokinetic model was used to obtain Ktrans and kep, by using the fast and medium blood curves, with and without considering the vascular term vp. The results showed that despite a rapid wash-in seen in some cases, the obtained vascular component was still low. The kep analyzed by using the medium blood curve was the best parameter to differentiate these 4 lesion groups. When the term vp was considered, it had a diagnostic value, but the kep might become less powerful.

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