Abstract #2304
Extra-ocular muscle fat fraction in thyroid eye disease
Tilak Das 1 , Andrew J Patterson 1 , Paul Meyer 2 , Rachna Murthy 2 , and Martin J Graves 1
1
Department of Radiology, Cambridge
University Hospitals NHS Foundation Trust, Cambridge,
United Kingdom,
2
Dept
of Ophthalmology, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, United Kingdom
Thyroid eye disease is an autoimmune disorder of orbital
tissues that can cause extra-ocular muscle inflammation
and enlargement. Fat infiltration of extra-ocular
muscles occurs in patients with chronic disease.
Quantification of fat in extra-ocular muscles has not
been previously described. The purpose of this study was
to evaluate the application of fat fraction measurements
to extra-ocular muscles in healthy volunteers and
patients with thyroid eye disease. Mean fat fraction was
significantly greater in thyroid eye disease patients
(p=0.021). This study demonstrates the feasibility of
measuring fat fraction in extra-ocular muscles as well
as detecting differences between groups.
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