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Abstract #2312

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: Evidence from Resting-State fMRI

Akinwunmi Oni-Orisan 1 , Mayank Kaushal 2 , Wenjun Li 1 , B. Doug Ward 1 , Aditya Vedantam 3 , Benjamin Kalinosky 2 , Dana Seslija 1 , Matthew Budde 1 , Brian Schmit 2 , Shi-Jiang Li 1 , Muqeet Vaishnavi 1 , and Shekar Kurpad 1

1 Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 2 Marquette University, Milwaukee, Wisconsin, United States, 3 Baylor College of Medicine, Houston, Texas, United States

We performed a resting-state functional magnetic resonance imaging (rs-fMRI) study to demonstrate alterations in cortical activation maps in patients with spinal cord injury (SCI). After prepreprocessing of functional data using Analysis of Functional NeuroImages (AFNI) software, region of interest (ROI) based analysis was carried out. A general pattern of decreased functional connectivity in sensorimotor cortex and increased connectivity in thalamus was observed in SCI patients compared to controls. Our results provide evidence of abnormal spontaneous brain activations in humans with SCI suggesting a possible SCI-induced reorganization of cerebral cortex on account of ongoing neural plasticity in the central nervous system.

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