Abstract #2312
Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: Evidence from Resting-State fMRI
Akinwunmi Oni-Orisan 1 , Mayank Kaushal 2 , Wenjun Li 1 , B. Doug Ward 1 , Aditya Vedantam 3 , Benjamin Kalinosky 2 , Dana Seslija 1 , Matthew Budde 1 , Brian Schmit 2 , Shi-Jiang Li 1 , Muqeet Vaishnavi 1 , and Shekar Kurpad 1
1
Medical College of Wisconsin, Milwaukee,
Wisconsin, United States,
2
Marquette
University, Milwaukee, Wisconsin, United States,
3
Baylor
College of Medicine, Houston, Texas, United States
We performed a resting-state functional magnetic
resonance imaging (rs-fMRI) study to demonstrate
alterations in cortical activation maps in patients with
spinal cord injury (SCI). After prepreprocessing of
functional data using Analysis of Functional NeuroImages
(AFNI) software, region of interest (ROI) based analysis
was carried out. A general pattern of decreased
functional connectivity in sensorimotor cortex and
increased connectivity in thalamus was observed in SCI
patients compared to controls. Our results provide
evidence of abnormal spontaneous brain activations in
humans with SCI suggesting a possible SCI-induced
reorganization of cerebral cortex on account of ongoing
neural plasticity in the central nervous system.
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