Abstract #2314
MiR-155 ablation protects spinal cord (SC) from damage in a mouse model of ischemic SC injury
Anna Bratasz 1 , Esmerina Tili 2,3 , Xiaomei Meng 2 , Jean-Jacques Michaille 4,5 , Lamia Bouhliqah 6 , Phillip G Popovich 7 , Cynthia Mcallister 8 , D Michele Basso 9 , Jos J Otero 10 , Claudia Kirsch 11 , Richard Burry 7 , Kimerly A Powell 1 , Peter Mohler 12 , Carlo M Croce 4 , and Hamdy Awad 2
1
Small Animal Imaging Core, The Ohio State
University, Columbus, Ohio, United States,
2
Department
of Anesthesiology, The Ohio State University, Ohio,
United States,
3
Department of Molecular
Virology, The Ohio State Univeristy, Ohio, United
States,
4
Department
of Molecular Virology, The Ohio State University, Ohio,
United States,
5
Universit
de Bourgogne, Dijon, France,
6
Department
of ENT, The Ohio State University, Ohio, United States,
7
Department
of Neuroscience, The Ohio State University, Ohio, United
States,
8
Nationwide Children Hospital, Ohio,
United States,
9
School
of Health and Rehabilitation Sciences, The Ohio State
University, Ohio, United States,
10
Department
of Pathology, The Ohio State University, Ohio, United
States,
11
Department
of Radiology, The Ohio State University, Ohio, United
States,
12
Dorothy
M. Davis Heart and Lung Research Institute, The Ohio
State University, Ohio, United States
MiR-155 ablation was evaluated for its protective effect
on ischemic cord injury (SC) in a mouse model of
thoraco-abdominal aortic aneurysm (TAAA) repair. MR
imaging was used for monitoring the paralysis event in
wild type and miR-155 knockout mice. MiR-155-/- mice
resulted in reduced number and delayed paralysis events.
There was a strong correlation between edema volume and
T2 relaxation time values of the SC grey matter in
paralyzed versus non-paralyzed mice. Edema was
correlated with histological observation of gray matter
damage. We believe that reducing miR-155 upregulation
after TAAA may be useful for reducing paralysis after
surgery.
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