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Abstract #2316

Injury alters the intrinsic functional connectivity network in spinal cord of monkeys

Li Min Chen 1,2 , Arabinda Mishra 1,2 , Feng Wang 1,2 , Pai-Feng Yang 1,2 , and John C. Gore 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Resting state fMRI has shown that intrinsic functional connectivity networks may be detected in the spinal cord of humans and anesthetized monkeys. The functional relevance of these networks, however, remains to be determined. One way to address this question is to modulate the network and then correlate the changes with behavioral and functional outcomes. In this study we examined the effects of unilateral spinal cord injury on the inter-regional correlation strengths of resting state fMRI signals between spinal horns of gray matter in spinal segments above or below the injury level.

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