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Abstract #2333

The many advantages of arterial spin labeling with long label duration

R. Marc Lebel 1,2 , Ajit Shankaranarayanan 3 , Eric E. Smith 4 , Cheryl McCreary 2 , Richard Frayne 2 , Weiying Dai 5 , and David C Alsop 5

1 GE Healthcare, Calgary, Alberta, Canada, 2 Radiology, University of Calgary, Calgary, Alberta, Canada, 3 GE Healthcare, Menlo Park, California, United States, 4 Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, 5 Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States

Pseudo-continuous arterial spin labeling (PCASL) is a method for non-contrast perfusion imaging that tags blood flowing across a labeling plane. The labeling plane is active for only a finite period of time prior to imaging. A 1.5 s labeling time is typical. It is well known that the signal-to-noise ratio increases with longer labeling times but additional benefits exist. We describe improved temporal stability and demonstrate a reduced sensitivity to arterial transit delays with longer labeling. Overall we recommend using a label duration that is much longer than what is commonly done.

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