Abstract #2333
The many advantages of arterial spin labeling with long label duration
R. Marc Lebel 1,2 , Ajit Shankaranarayanan 3 , Eric E. Smith 4 , Cheryl McCreary 2 , Richard Frayne 2 , Weiying Dai 5 , and David C Alsop 5
1
GE Healthcare, Calgary, Alberta, Canada,
2
Radiology,
University of Calgary, Calgary, Alberta, Canada,
3
GE
Healthcare, Menlo Park, California, United States,
4
Clinical
Neurosciences, University of Calgary, Calgary, Alberta,
Canada,
5
Radiology,
Beth Israel Deaconess Medical Center and Harvard Medical
School, Boston, Massachusetts, United States
Pseudo-continuous arterial spin labeling (PCASL) is a
method for non-contrast perfusion imaging that tags
blood flowing across a labeling plane. The labeling
plane is active for only a finite period of time prior
to imaging. A 1.5 s labeling time is typical. It is well
known that the signal-to-noise ratio increases with
longer labeling times but additional benefits exist. We
describe improved temporal stability and demonstrate a
reduced sensitivity to arterial transit delays with
longer labeling. Overall we recommend using a label
duration that is much longer than what is commonly done.
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