Scan-Rescan Variability in DCE-MRI Comparing Signal Difference and Concentration-Based Methods

Dual-baseline DCE-MRI data for 43 patients drawn from three Phase 1 clinical trials are analyzed both with and without conversion of data from signal intensity values to millimolar gadolinium concentration. Both model-based (KTrans) and model-free (AUCBN) parameters are calculated. Coefficients of variability are estimated for both parameters using both methods, and systematic bias between the two methods is calculated. Variability is approximately 25% lower for both parameters using signal intensity, primarily because conversion to gadolinium concentration is less robust to patient motion and other image quality issues. Absolute values of both parameters are systematically higher using signal difference methods.

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