Cerebral Blood Flow and Metabolism in Patients with Sickle Cell Disease

In sickle cell disease (SCD) stroke is common, however accurate quantification of basal cerebral oxygen consumption (CMRO2) is unknown. We measured brain volume, cerebral blood flow (CBF) and cerebral venous saturation (SvO2) in patients with SCD using phase contrast and TRUST MRI to address questions regarding cerebral metabolism. We found patients with SCD to have 167% the CBF of healthy controls, a higher oxygen delivery and a calculated CMRO2. Our study is the first to demonstrate elevated cerebral metabolism in SCD, mirroring increases in global resting energy expenditure and peripheral metabolic rate described by others.

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