Meeting Banner
Abstract #2375

Efficient detection of bound potassium and sodium using TQTPPI pulse sequence

Victor D. Schepkin 1 , Boris M. Odintsov 2 , Ilya Litvak 1 , Peter L. Gor'kov 1 , William W. Brey 1 , Andreas Neubauer 3 , and Thomas F. Budinger 4

1 NHMFL/FSU, Tallahassee, Florida, United States, 2 UIUC, Illinois, United States, 3 Heidelberg University, Germany, 4 LBNL/UCB, California, United States

A novel way to detect bound potassium and sodium in vivo was explored based on triple quantum signals without filtration. The method is based on time proportional phase increments, allowing the detection of bound ions as a separate peak on triple frequency relative to single quantum MR signals. Bound ions signals are acquired in the same way and efficiently for a wide range of binding strengths. This is advantageous compared to typical TQF methods, especially during diseases or interventions. A comparison of TQTPPI signals in rat head revealed almost two times more effective binding of potassium relative to sodium.

This abstract and the presentation materials are available to members only; a login is required.

Join Here