Abstract #2375
Efficient detection of bound potassium and sodium using TQTPPI pulse sequence
Victor D. Schepkin 1 , Boris M. Odintsov 2 , Ilya Litvak 1 , Peter L. Gor'kov 1 , William W. Brey 1 , Andreas Neubauer 3 , and Thomas F. Budinger 4
1
NHMFL/FSU, Tallahassee, Florida, United
States,
2
UIUC,
Illinois, United States,
3
Heidelberg
University, Germany,
4
LBNL/UCB,
California, United States
A novel way to detect bound potassium and sodium in vivo
was explored based on triple quantum signals without
filtration. The method is based on time proportional
phase increments, allowing the detection of bound ions
as a separate peak on triple frequency relative to
single quantum MR signals. Bound ions signals are
acquired in the same way and efficiently for a wide
range of binding strengths. This is advantageous
compared to typical TQF methods, especially during
diseases or interventions. A comparison of TQTPPI
signals in rat head revealed almost two times more
effective binding of potassium relative to sodium.
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