Sensitivity improvement under parallel detection in CW-EPR imaging

The purpose of this study was to improve the signal-to-noise ratio (SNR) in the parallel EPR detection scheme using multiple channels and to demonstrate the feasibility of in vivo EPR imaging with parallel EPR detection. This improvement in sensitivity leads to a decrease in the image acquisition time in three-dimensional EPR imaging. EPR imaging of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (3-CP) in a subject mouse was demonstrated with a surface coil array and a parallel detection scheme. In addition to in vivo mouse imaging, tests were also performed with phantoms filled with nitroxyl radical solutions.

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