Abstract #2450
Proton-constrained CMRO 2 Quantification with direct 17 O-MRI at 3 Tesla
Dmitry Kurzhunov 1 , Robert Borowiak 1,2 , Philipp Wagner 1 , Marco Reisert 1 , and Michael Bock 1
1
Department of Radiology Medical Physics,
University Medical Center Freiburg, Freiburg,
Baden-Wrttemberg, Germany,
2
German
Cancer Consortium (DKTK), German Cancer Research Center
(DKFZ), Heidelberg, Baden-Wrttemberg, Germany
In this work iterative proton-constrained reconstruction
of
17
O
MR data set using an anisotropic non-homogeneous
diffusion operator is proposed. It was tested on a
17
O
brain phantom and on a data set obtained from a dynamic
17
O
MRI experiment.
17
O
images show a higher SNR and superior quality compared
to Kaiser-Bessel re-gridding method. Localized CMRO
2
quantification
with
1
H
constrained in a human frontal lobe and in a brain
phantom show most precise CMRO
2
values
in GM and WM. For GM it is in good agreement with
literature
15
O-PET
data.
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