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Abstract #2478

Partial Volume Correction based on Spatial Variant Point Spread Function for Simultaneous PET-MR Imaging

Chenguang Peng 1 , Jinchao Wu 1 , Xingfeng Shao 1,2 , Yingmao Chen 3 , Quanzheng Li 4 , Georges El Fakhr 4 , and Kui Ying 1

1 Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Department of Engineering, Beijing, China, 2 Department of Bioengineering, UCLA, California, United States, 3 Department of Nuclear Medicine, The general hospital of Chinese People's Liberation, Beijing, China, Beijing, China, 4 Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, United States

PET image has relatively low resolution, and partial volume effect (PVE) is one of the major reason for this. Hybrid PET-MRI system offers us a great opportunity to synthesis PET and MRI, and MRI can provide PET with high resolution anatomical image which is a great supplementary information to correct PVE. In traditional method, point spread function is usually used to described PVE and is regarded as a spatial invariant constant which is not true in real PET system. In this work, we proposed a new method that considered spatial variant point spread function.

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