Abstract #2480
Rapid segmentation of the cervical spinal cord on 3D MRI data with cord image analyzer (cordial): application to three-year follow-up data of MS patients with a progressive disease course
Michael Amann 1 , Simon Pezold 2 , Yvonne Naegelin 3 , Ketut Fundana 2 , Michaela Andelova 3 , Katrin Weier 3 , Christoph Stippich 4 , Ludwig Kappos 3 , Philippe Cattin 2 , and Till Sprenger 1
1
Neurology/Neuroradiology, University
Hospital Basel, Basel, BS, Switzerland,
2
Medical
Image Analysis Center (MIAC), University of Basel,
Basel, BS, Switzerland,
3
Neurology,
University Hospital Basel, Basel, BS, Switzerland,
4
Neuroradiology,
University Hospital Basel, Basel, BS, Switzerland
The "cord image analyzer (cordial)" pre-segments the
spinal cord (SC) based on the continuous
max-flow-approach, combined with a cross-sectional
similarity prior. The SC surface is reconstructed by
locating SC boundary based on image intensities. The
cervical SC volume (CSCV) is defined by cutting planes
perpendicular to the SC centerline. Reliability of
cordial was assessed on controls with
coefficients-of-variation of less than 1%. Applicability
to clinical data was tested on a cohort of 48 MS
patients. Multiple regression analysis revealed
significant relation between CSCV loss and EDSS change.
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