Abstract #2498
How to improve the accuracy of total water content measured using T 2 relaxation
Sandra M. Meyers 1 , Shannon H. Kolind 2 , and Alex L. MacKay 1,3
1
Physics and Astronomy, University of British
Columbia, Vancouver, BC, Canada,
2
Medicine,
University of British Columbia, Vancouver, BC, Canada,
3
Radiology,
University of British Columbia, Vancouver, BC, Canada
Multi-component T2 relaxation is widely used to measure
the myelin water fraction, but it can also be applied to
measure the total water content (TWC). This work is the
first to estimate theoretical errors in T2-based TWC
measurement with simulations, and determine the impact
of factors including the signal to noise ratio, flip
angle inaccuracies (B1+ inhomogeneity), and Rician noise
on the accuracy of TWC estimation. Simulations
demonstrated that TWC could be measured with T2 to a
high degree of accuracy (<3%), even in the presence of
B1+ inhomogeneity and Rician noise, and suggestions are
given to improve accuracy further.
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