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Abstract #2521

In Vivo Waveguide Elastography of White Matter Tracts in the Full Human Brain

Anthony Joseph Romano 1 , Jing Guo 2 , Michael Scheel 2 , Sebastian Hirsch 2 , Juergen Braun 3 , and Ingolf Sack 2

1 Physcial Acoustics, Naval Research Laboratory, Washington, DC, United States, 2 Radiology, Charite-Universitatsmedizin, Berlin, Germany, 3 Medical Informatics, Charite-Universitatsmedizin, Berlin, Germany

Waveguide Elastography combines Magnetic Resonance Elastography, Diffusion Tensor Imaging and Orthotropic inversions for the analysis of the anisotropic properties of white matter. Previously, this method was applied to the Cortico-spinal tracts of healthy human volunteers and to patients diagnosed with Amyotrophic Lateral Sclerosis. Here we apply this approach to the classification of the anisotropic properties of the 12 major white matter tracts in the human brain. This method is intended as a new modality to assess white matter structure and health by means of the evaluation of the anisotropic elasticity tensor of nerve fibers.

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