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Abstract #2566

Comparison of breath-holding and respiratory gating T2* mapping in the heart and liver for thalassemia major patients

Xiaodong Chen 1,2 , Zuoquan Zhang 3 , Qihua Yang 1 , Zebin Luo 2 , Ziliang Cheng 1 , Jiaji Mao 1 , Queenie Chan 4 , Hua Guo 5 , and Biling Liang 1

1 Sun Yat-Sen Memorial Hospital, Guangzhou, Guangdong, China, 2 Affiliated hospital of Guangdong Medical College, Zhanjiang, Guangdong, China, 3 The Fifth Affiliated Hospital of Sun Yat-Sen University, Guangdong, China, 4 Philips Healthcare, Hong Kong, China, 5 Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

With the development of MRI techniques, T2* mapping is becoming the routine examination for evaluation of the iron level of the heart and liver in TM patients. Generally, the common T2* sequence is scanned with one breath hold and less attention is paid to motion artifact reduction because most adults can suspend respiration on command. However, as the recommended age to start the first cardiac MRI screening in TM patients has become younger, more and more children with TM will get T2* examination and most of them are generally less able to suspend respiration. In this study, We optimized a technique of T2* respiratory gating, developed and tested the use of respiratory gating to decrease motion artifacts in pediatric heart and liver T2* MRI examinations. From the preliminary study it suggests that, comparing to the results of breath-hold T2* scanning, the accuracy and reproducibility of respiratory gating method are good enough to be used in the clinical practice.

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