Abstract #2606
Measurement of quantitative myocardial blood volume and water exchange using ferumoxytol
Neil Chatterjee 1 , Octavia Bane 2 , Bruce Spottiswoode 3 , James Carr 4 , and Timothy Carroll 4
1
Biomedical Engineering, Northwestern
University, Chicago, IL, United States,
2
Mount
Sinai, NY, United States,
3
Siemens
Healthcare, Chicago, IL, United States,
4
Radiology,
Northwestern University, IL, United States
Quantitative measurement of myocardial blood volume
(MBV) may have importance as a biomarker for
cardiovascular disease, but measurement is complicated
by errors introduced by water exchange between the
intravascular and extravascular compartments. Here, we
use ferumoxytol to measure water exchange rates in the
myocardium and calculate quantitative MBV in a cohort of
healthy volunteers. Our measured MBV and water exchange
frequencies fall within the expected range seen in the
literature from animal studies.
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