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Abstract #2606

Measurement of quantitative myocardial blood volume and water exchange using ferumoxytol

Neil Chatterjee 1 , Octavia Bane 2 , Bruce Spottiswoode 3 , James Carr 4 , and Timothy Carroll 4

1 Biomedical Engineering, Northwestern University, Chicago, IL, United States, 2 Mount Sinai, NY, United States, 3 Siemens Healthcare, Chicago, IL, United States, 4 Radiology, Northwestern University, IL, United States

Quantitative measurement of myocardial blood volume (MBV) may have importance as a biomarker for cardiovascular disease, but measurement is complicated by errors introduced by water exchange between the intravascular and extravascular compartments. Here, we use ferumoxytol to measure water exchange rates in the myocardium and calculate quantitative MBV in a cohort of healthy volunteers. Our measured MBV and water exchange frequencies fall within the expected range seen in the literature from animal studies.

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