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Abstract #2612

Verification of the intra-voxel incoherent motion (IVIM) model in the porcine heart

Constantin von Deuster 1,2 , Christian T. Stoeck 1,2 , Lukas Wissmann 2 , Georg Spinner 2 , Thea Fleischmann 3,4 , Maximilian Y. Emmert 4,5 , Nikola Cesarovic 4 , and Sebastian Kozerke 1,2

1 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 3 Institute of Laboratory Animal Science, University of Zurich, Zurich, Switzerland, 4 Department of Surgical Research, University Hospital Zurich, Zurich, Switzerland, 5 Swiss Center of Regenerative Medicine, Zurich, Switzerland

Intra-voxel incoherent motion (IVIM) has the potential to measure perfusion without contrast agent administration. Its application to the heart however remains challenging due to cardiac and respiratory motion. In this work IVIM data was acquired with a second order motion compensated diffusion weighted spin echo sequence in a pig model with myocardial infarction. The IVIM theory was validated by pre- and post-mortem comparison in the same animal. Infarcted area identified by a low perfusion fraction in the IVIM model agreed with dynamic contrast-enhanced myocardial perfusion imaging.

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