Abstract #2650
Noninvasive Three-dimensional Mapping of endothelial dysfunction in Cardiac Ischemia by Dynamic Contrast Enhanced Magnetic Resonance Imaging Using Albumin-based Contrast Agent
Katrien Vandoorne 1 , Moriel H. Vandsburger 2 , Yue Han 1 , Igor Jacobs 1 , Hagit Dafni 3 , Klaas Nicolay 1 , and Gustav J. Strijkers 1,4
1
Department of Biomedical Engineering,
Eindhoven University of Technology, Eindhoven,
Netherlands,
2
Department
of Physiology, University of Kentucky, Kentucky, United
States,
3
Weizmann
Institute of Science, Israel,
4
Academic
Medical Center, Amsterdam, Netherlands
This study aimed to develop a method to quantify the
dynamics of a blood pool contrast agent for mapping the
myocardial fractional blood volume, a measure for
microvascular density and permeability or the rate of
extravasation from myocardial blood vessels using in
vivo dynamic contrast enhanced (DCE) MRI. This method
enabled noninvasive 3D quantitative mapping of
microvascular density and initial rate of extravasation
of high-molecular-weight contrast materials in the
distinct regions of infarcted myocardium with altered
endothelial function and has the potential to track
endothelial dysfunction in models of myocardial healing.
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