Abstract #2701
Evaluate Myocardial Dyssynchrony Index in Left Ventricle for Marfan Syndrome Patients by Using Phase-Contrast Magnetic Resonance Imaging
Tzu-Yu chou 1,2 , Hsin-Hui Chiu 3 , Wen-Yih Isaac Tseng 4 , Marius Menza 5 , and Hsu-Hsia Peng 2
1
Institute of Biomedical Engineering,
National Taiwan University, taipei, taiwan, Taiwan,
2
Department
of Biomedical Engineering and Environmental Sciences,
National Tsing Hua University, Hsinchu, Taiwan,
3
Department
of Pediatrics, Taipei Medical University Hospital,
Taipei, Taiwan, Taiwan,
4
Center
for Optoelectronic Biomedicine, College of Medicine,
National Taiwan University, Taiwan,
5
Medical
Physics, Department of Radiology, University Hospital
Freiburg, Freiburg, Germany
Marfan syndrome is a multi-systemic connective disorder
and an inherent mutation affecting fibrillin-1 gene. In
this study, we used dark-blood tissue phase mapping with
PC-MRI to quantify the left ventricular myocardial
function and the myocardial dyssynchrony index. The
indices were compared with age-matched normal controls
so that to show the myocardial abnormality of MFS. MFS
demonstrated dyssynchronized TTPr or TTPz either in
systole or in diastole. In conclusion, the investigated
LV myocardial function and the quantified myocardial DI
can reflect the abnormal dyssynchronized conditions for
MFS and provide helpful information to evaluate
myocardial function before deteriorated cardiac function
was shown.
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