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Abstract #2701

Evaluate Myocardial Dyssynchrony Index in Left Ventricle for Marfan Syndrome Patients by Using Phase-Contrast Magnetic Resonance Imaging

Tzu-Yu chou 1,2 , Hsin-Hui Chiu 3 , Wen-Yih Isaac Tseng 4 , Marius Menza 5 , and Hsu-Hsia Peng 2

1 Institute of Biomedical Engineering, National Taiwan University, taipei, taiwan, Taiwan, 2 Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 3 Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan, Taiwan, 4 Center for Optoelectronic Biomedicine, College of Medicine, National Taiwan University, Taiwan, 5 Medical Physics, Department of Radiology, University Hospital Freiburg, Freiburg, Germany

Marfan syndrome is a multi-systemic connective disorder and an inherent mutation affecting fibrillin-1 gene. In this study, we used dark-blood tissue phase mapping with PC-MRI to quantify the left ventricular myocardial function and the myocardial dyssynchrony index. The indices were compared with age-matched normal controls so that to show the myocardial abnormality of MFS. MFS demonstrated dyssynchronized TTPr or TTPz either in systole or in diastole. In conclusion, the investigated LV myocardial function and the quantified myocardial DI can reflect the abnormal dyssynchronized conditions for MFS and provide helpful information to evaluate myocardial function before deteriorated cardiac function was shown.

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