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Abstract #2739

Cerebrospinal Fluid (CSF) Flow in Pediatric Patients with Type I Chiari Malformation Compared to Control Subjects

Samir Sarda 1 , Joshua J. Chern 1 , Nilesh K. Desai 2 , and John Oshinski 2,3

1 Pediatric Neurosurgery Associates, Children's Healthcare of Atlanta, Atlanta, Georgia, United States, 2 Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, United States, 3 Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States

In the pediatric population with Type I Chiari malformation (CM-I), cerebrospinal fluid (CSF) flow is known to be obstructed due to the herniation of cerebellar tissue at the level of the foramen magnum. This study examined differences in CSF flow between pediatric patient subjects, adult subjects, and pediatric controls. By utilizing ECG-gated, phase contrast MR to quantify flow, we found that pediatric subjects exhibit higher peak systolic and diastolic CSF flow velocities compared to adults. Additionally, CSF flow dynamics appear to be disrupted only in the pediatric CM-I population with syringomyelia when compared to controls.

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