Cerebrospinal Fluid (CSF) Flow in Pediatric Patients with Type I Chiari Malformation Compared to Control Subjects
Samir Sarda 1 , Joshua J. Chern 1 , Nilesh K. Desai 2 , and John Oshinski 2,3
Pediatric Neurosurgery Associates,
Children's Healthcare of Atlanta, Atlanta, Georgia,
of Radiology and Imaging Sciences, Emory University
School of Medicine, Atlanta, Georgia, United States,
of Biomedical Engineering, Georgia Institute of
Technology, Atlanta, Georgia, United States
In the pediatric population with Type I Chiari
malformation (CM-I), cerebrospinal fluid (CSF) flow is
known to be obstructed due to the herniation of
cerebellar tissue at the level of the foramen magnum.
This study examined differences in CSF flow between
pediatric patient subjects, adult subjects, and
pediatric controls. By utilizing ECG-gated, phase
contrast MR to quantify flow, we found that pediatric
subjects exhibit higher peak systolic and diastolic CSF
flow velocities compared to adults. Additionally, CSF
flow dynamics appear to be disrupted only in the
pediatric CM-I population with syringomyelia when
compared to controls.
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