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Abstract #2745

Hemodynamic abnormalities reflected by high OSI as a potential trigger to atherosclerosis in non-dilated lower abdominal aorta.

Masataka Sugiyama 1 , Yasuo Takehara 2 , Naoki Oishi 2 , Marcus Alley 3 , Tetsuya Wakayama 4 , Atsushi Nozaki 4 , Hiroyuki Kabasawa 4 , Shuhei Yamashita 1 , and Harumi Sakahara 1

1 Radiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan, 2 Radiology, Hamamatsu University Hospital, Shizuoka, Japan, 3 Radiology, Stanford University School of Medicine, California, United States, 4 Applied Science Laboratory Asia Pacific, GE Healthcare Japan, Tokyo, Japan

To test the hypothesis that initial trigger for atherosclerosis in the lower aortic wall is abnormal hemodynamics, flow dynamics within the non-dilated aorta were measured with 3D cine PC MR imaging (4D Flow) and the data were compared to CT grades of aortic atherosclerosis. Statistical analysis in relation to the aortic wall atheroma, only the oscillatory shear index (OSI) was the significant determinant. Streamline analysis depicted prominent backflow and turbulent flow in the region with higher OSI. The abnormal flow dynamics reflected by high OSI might be a potential trigger to the atherosclerosis of non-dilated lower aorta.

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