Abstract #2745
Hemodynamic abnormalities reflected by high OSI as a potential trigger to atherosclerosis in non-dilated lower abdominal aorta.
Masataka Sugiyama 1 , Yasuo Takehara 2 , Naoki Oishi 2 , Marcus Alley 3 , Tetsuya Wakayama 4 , Atsushi Nozaki 4 , Hiroyuki Kabasawa 4 , Shuhei Yamashita 1 , and Harumi Sakahara 1
1
Radiology, Hamamatsu University School of
Medicine, Hamamatsu, Shizuoka, Japan,
2
Radiology,
Hamamatsu University Hospital, Shizuoka, Japan,
3
Radiology,
Stanford University School of Medicine, California,
United States,
4
Applied
Science Laboratory Asia Pacific, GE Healthcare Japan,
Tokyo, Japan
To test the hypothesis that initial trigger for
atherosclerosis in the lower aortic wall is abnormal
hemodynamics, flow dynamics within the non-dilated aorta
were measured with 3D cine PC MR imaging (4D Flow) and
the data were compared to CT grades of aortic
atherosclerosis. Statistical analysis in relation to the
aortic wall atheroma, only the oscillatory shear index
(OSI) was the significant determinant. Streamline
analysis depicted prominent backflow and turbulent flow
in the region with higher OSI. The abnormal flow
dynamics reflected by high OSI might be a potential
trigger to the atherosclerosis of non-dilated lower
aorta.
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