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Abstract #2775

Validation of Extra-Axonal Diffusion Spectrum Model with Frequency-Dependent Restriction

Wilfred W Lam 1 , Bernard Siow 2,3 , Lauren Burcaw 4 , Daniel C Alexander 2,3 , Mark F Lythgoe 2 , Karla L Miller 1 , and Saad Jbabdi 1

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3 Centre for Medical Image Computing, University College London, London, United Kingdom, 4 Department of Radiology, New York University School of Medicine, New York, NY, United States

Diffusion imaging has enormous potential for quantitative measurements of geometric properties that are directly relevant to brain function and pathology. We validate a previously presented diffusion spectrum model of the extra-axonal space using a phantom consisting of randomly packed solid fibers. Measured diffusion spectra and estimated microstructural properties of the phantom are compared with those from Monte Carlo simulations and model fitting. The model accurately captures salient properties of the diffusion spectrum and estimates the microstructural properties of the phantom.

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