Abstract #2775
Validation of Extra-Axonal Diffusion Spectrum Model with Frequency-Dependent Restriction
Wilfred W Lam 1 , Bernard Siow 2,3 , Lauren Burcaw 4 , Daniel C Alexander 2,3 , Mark F Lythgoe 2 , Karla L Miller 1 , and Saad Jbabdi 1
1
FMRIB Centre, University of Oxford, Oxford,
United Kingdom,
2
Centre
for Advanced Biomedical Imaging, University College
London, London, United Kingdom,
3
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
4
Department
of Radiology, New York University School of Medicine,
New York, NY, United States
Diffusion imaging has enormous potential for
quantitative measurements of geometric properties that
are directly relevant to brain function and pathology.
We validate a previously presented diffusion spectrum
model of the extra-axonal space using a phantom
consisting of randomly packed solid fibers. Measured
diffusion spectra and estimated microstructural
properties of the phantom are compared with those from
Monte Carlo simulations and model fitting. The model
accurately captures salient properties of the diffusion
spectrum and estimates the microstructural properties of
the phantom.
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