Neurite Orientation Dispersion and Density Imaging could show the microstractual changes of Cortico-Spinal Tract in patients with Idiopathic Normal Pressure Hydrocephalus
Kohei Tsuruta 1,2 , Ryusuke Irie 2 , Masaaki Hori 2 , Issei Fukunaga 1,2 , Yoshitaka Masutani 3 , Kuohei Kamiya 4 , Akira Nishikori 1,2 , Mariko Yoshida 2 , Michimasa Suzuki 2 , Masakazu Miyajima 2 , Madoka Nakajima 2 , Koji Kamagata 2 , Hajime Arai 2 , Atsushi Nakanishi 2 , Shigeki Aoki 2 , and Atsushi Senoo 1
Tokyo Metropolitan University, Arakawa-ku,
University School of Medicine, Bunkyo-ku, Tokyo, Japan,
of Information Sciences and Graduate School of
Information Sciences, Hiroshima City University,
The University of Tokyo Hospital, Tokyo, Japan
Neurite Orientation Dispersion and Density Imaging
(NODDI) is a recently developed technique to evaluate
the restricted diffusion. This study was to evaluate
diffusional changes of cortico-spinal tract (CST) in
patients with idiopathic normal pressure hydrocephalus
(iNPH) by NODDI. NODDI produces maps of intra-cellular
volume fraction (ICVF), orientation dispersion index
(ODI) and isotropic volume fraction (iso VF). In the
iNPH patients, ODI of CST significantly decreased.
Decreased ODI suggested that axon was compressed and
oriented. NODDI could show the microstructural changes
on CSTs in the iNPH patients.
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