Abstract #2785
Estimation of Microstructural Properties of Fixed Corpus Callosum from OGSE Measurements
Wilfred W Lam 1 , Bernard Siow 2,3 , Sean Foxley 1 , Steven A Chance 4 , Rogier B Mars 1,5 , Daniel C Alexander 2,3 , Mark F Lythgoe 2 , Karla L Miller 1 , and Saad Jbabdi 1
1
FMRIB Centre, University of Oxford, Oxford,
United Kingdom,
2
Centre
for Advanced Biomedical Imaging, University College
London, London, United Kingdom,
3
Centre
for Medical Image Computing, University College London,
London, United Kingdom,
4
Division
of Clinical Neurology, University of Oxford, Oxford,
United Kingdom,
5
Department
of Experimental Psychology, University of Oxford,
Oxford, United Kingdom
Diffusion imaging has enormous potential for
quantitative measurements of geometric properties that
are directly relevant to brain function and pathology.
We combine diffusion spectrum models of the intra- and
extra-axonal space, where axons are idealized as
randomly packed, parallel, impermeable cylinders with a
distribution of radii. Model predictions are compared
with Monte Carlo simulations and the model is fitted to
diffusion spectra measured in brain specimens. The model
accurately captures salient properties of the simulated
diffusion spectra and estimates microstructural
properties of the tissue that are in agreement with
those found in literature.
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