Abstract #2788
Isotropic Diffusion Weighting Provides Insight on Diffusion Compartments in Human Brain White Matter In vivo
Bibek Dhital 1,2 , Elias Kellner 3 , Marco Reisert 3 , and Valerij G. Kiselev 3
1
German Cancer Consortium (DKTK), Heidelberg,
Baden, Germany,
2
Department
of Diagnostic Radiology, University Medical Center,
Freiburg, Baden, Germany,
3
University
Medical Center, Freiburg, Baden, Germany
Biophysical modeling of diffusion weighted MR signal is
an ill-defined inverse problem that needs simplified
assumptions regarding different fitting parameters.
Using a simple multi-shell diffusion protocol and an
isotropic weighted diffusion sequence, we experimentally
address two common assumptions made in different models
different models: (i) the presence of isotropically
restricted water compartment and (ii) the relation
between ADC of extra and intraaxonal water in single
fiber bundles. The results show that isotropically
restricted compartment have a negligible contribution to
the signal. Additionally we find that intraaxonal axial
diffusivity is greater than extraaxonal axial
diffusivity. The results show that isotropically
restricted compartment have a negligible contribution to
the signal. Additionally we find that intraaxonal axial
diffusivity is greater than extraaxonal axial
diffusivity.
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