Abstract #2790
Investigation of NODDI estimates at two different magnetic fields along the rat corpus callosum
Nicolas Kunz 1 , Stphane Sizonenko 2 , Petra Susan Hppi 2 , Rolf Gruetter 1,3 , and Yohan van de Looij 4
1
CIBM-AIT, EPFL, Lausanne, Vaud, Switzerland,
2
Division
of Child Growth and Development, University of Geneva,
Geneva, Switzerland,
3
Department
of Radiology, University of Geneva and Lausanne,
Lausanne, Switzerland,
4
University
of Geneva, Division of Child Growth and Development,
Geneva, Switzerland
It has been shown that magnetic field strength and
diffusion time (t
diff
) has an influence on
diffusion tensor imaging derived parameters, limiting
multicentre comparisons with different MR systems. The
aim of this work was to investigate effect of B0 and t
diff
on
NODDI estimated microstructural parameters to better
understand this field dependency. We demonstrate the
feasibility of reconstructing NODDI model in the rodent
brain in-vivo at ultra-high magnetic field using
multi-b-value shells acquisition. These preliminary
results suggest that FA changes along the CC are not
only due to differences in axonal diameter but also to
axonal orientation dispersion differences as depicted by
NODDI results.
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