Abstract #2792
Confounding effects of imaging gradients in stimulated echo: case of diffusion exchange imaging
Samo Lasic 1 , Henrik Lundell 2 , Casper Kaae Snderby 2 , Daniel Topgaard 3 , and Tim B. Dyrby 2
1
CR Development, Lund, Skne, Sweden,
2
Danish
Research Centre for Magnetic Resonance, Copenhagen
University Hospital, Hvidovre, Denmark,
3
Physical
Chemistry, Lund University, Lund, Skne, Sweden
In multiple diffusion encoding sequences with stimulated
echo, additional diffusion weighting introduced by the
slice and crusher gradients (together known as butterfly
gradients) may significantly disrupt the experimental
design and introduce a bias that cannot be easily
mitigated. We discuss the bias caused by butterfly
gradients in Filter EXchange Imaging (FEXI) and their
possible confounding effect on the measurement of
apparent exchange rate (AXR). The effect is exemplified
by the FEXI data acquired on a yeast suspension.
Simulation results indicate that reducing slice
thickness in FEXI leads to increasingly underestimated
AXR values.
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