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Abstract #2792

Confounding effects of imaging gradients in stimulated echo: case of diffusion exchange imaging

Samo Lasic 1 , Henrik Lundell 2 , Casper Kaae Snderby 2 , Daniel Topgaard 3 , and Tim B. Dyrby 2

1 CR Development, Lund, Skne, Sweden, 2 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark, 3 Physical Chemistry, Lund University, Lund, Skne, Sweden

In multiple diffusion encoding sequences with stimulated echo, additional diffusion weighting introduced by the slice and crusher gradients (together known as butterfly gradients) may significantly disrupt the experimental design and introduce a bias that cannot be easily mitigated. We discuss the bias caused by butterfly gradients in Filter EXchange Imaging (FEXI) and their possible confounding effect on the measurement of apparent exchange rate (AXR). The effect is exemplified by the FEXI data acquired on a yeast suspension. Simulation results indicate that reducing slice thickness in FEXI leads to increasingly underestimated AXR values.

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