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Abstract #2810

Connectome-like quality diffusion MRI in 13 minutes - Improving diffusion MRI spatial resolution with denoising

Samuel St-Jean 1 , Guillaume Gilbert 2 , and Maxime Descoteaux 1

1 Sherbrooke Connectivity Imaging Lab (SCIL), Universit de Sherbrooke, Sherbrooke, Qubec, Canada, 2 MR Clinical Science, Philips Healthcare, Markham, Ontario, Canada

Diffusion Weighted Images datasets are acquired at a low spatial resolution due to decreased SNR and increased acquisition time as the voxel size is reduced. Achieving high spatial resolution improves the specificity of reconstructed tracts and diffusion features, which might not be present at a lower spatial resolution. We show that high resolution DWIs are achievable thanks to proper denoising and favorably compare to the HCP dataset, while still being feasible in 13 minutes on a standard 3T clinical scanner. This could reveal new anatomical details, which are not achievable at the spatial resolution currently used in diffusion MRI.

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