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Abstract #2820

Diffusion reconstruction by combining Spherical Harmonics and Generalized Q-Sampling Imaging

Sudhir K Pathak 1 , Catherine Fissell 2 , Deepa Krishnaswamy 1 , Sowmya Aggarwal 1 , Rebecca Hachey 2 , and Walter Schneider 2

1 Bioengineering, University Of Pittsburgh, Pittsburgh, PA, United States, 2 Psychology, University Of Pittsburgh, Pittsburgh, PA, United States

There are different diffusion reconstruction algorithms reported in the literature that can be used to assess the micro-structure of white matter tissue in the human brain. Most notably, constrained spherical deconvolution (CSD) is used for single shell (constant b-value) image acquisitions and Generalized Q-sampling imaging (GQI) is used for Diffusion Spectrum Imaging and Multi-shell image acquisitions. A new reconstruction method is proposed that combines CSD and GQI to estimate the spherical harmonics coefficients directly from the diffusion signal. The proposed method produce improved estimates of fiber directions and sharper ODF using CSD and better tractography.

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