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Abstract #2823

Analysis of Neuronal Fiber Orientation distribution in Gray Matter and at Gray-White Matter Borders using Spherical Deconvolution of high-resolution (1.4 mm) 3 7T DWI Data

Ralf Luetzkendorf 1 , Robin M Heidemann 2 , Thorsten Feiweier 2 , Joerg Stadler 3 , Sebastian Baecke 1 , Michael Luchtmann 4 , and Johannes Bernarding 1

1 Department for Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany, 2 Siemens Healthcare, Erlangen, Germany, 3 Leibniz Institute for Neurobiology, Magdeburg, Germany, 4 Department of Neurosurgery, University of Magdeburg, Magdeburg, Germany

To analyze fiber orientation density within gray matter (GM) and at gray-white matter borders (GWMB) spherical de-convolution was applied to 1.4 mm isotropic 7T DWI data leading to high-resolution fiber orientation distribution maps (FOD). Data were post-processed with FSL and MRTrix 0.2. Anatomy, DWI and vector schemes were registered to each other. The high resolution decreased partial volume effects in GM allow for clear differentiation of fiber orientations in GM and GWMB in the ODF maps. Fibers in gray matter are oriented perpendicular to local GM-surfaces. Along the rim of the gyri, sharp bending of fibers can be unambiguously seen at GWMB.

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