Abstract #2823
Analysis of Neuronal Fiber Orientation distribution in Gray Matter and at Gray-White Matter Borders using Spherical Deconvolution of high-resolution (1.4 mm) 3 7T DWI Data
Ralf Luetzkendorf 1 , Robin M Heidemann 2 , Thorsten Feiweier 2 , Joerg Stadler 3 , Sebastian Baecke 1 , Michael Luchtmann 4 , and Johannes Bernarding 1
1
Department for Biometry and Medical
Informatics, University of Magdeburg, Magdeburg,
Germany,
2
Siemens
Healthcare, Erlangen, Germany,
3
Leibniz
Institute for Neurobiology, Magdeburg, Germany,
4
Department
of Neurosurgery, University of Magdeburg, Magdeburg,
Germany
To analyze fiber orientation density within gray matter
(GM) and at gray-white matter borders (GWMB) spherical
de-convolution was applied to 1.4 mm isotropic 7T DWI
data leading to high-resolution fiber orientation
distribution maps (FOD). Data were post-processed with
FSL and MRTrix 0.2. Anatomy, DWI and vector schemes were
registered to each other. The high resolution decreased
partial volume effects in GM allow for clear
differentiation of fiber orientations in GM and GWMB in
the ODF maps. Fibers in gray matter are oriented
perpendicular to local GM-surfaces. Along the rim of the
gyri, sharp bending of fibers can be unambiguously seen
at GWMB.
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