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Abstract #2847

Pushing the limits of ex-vivo diffusion MRI and tractography of the human brain

Christian Wieseotte 1,2 , Thomas Witzel 3 , Jon Polimeni 3 , Aapo Nummenmaa 3 , Bernhard Gruber 4 , Laura Schreiber 1,5 , and Lawrence Wald 3

1 Department of Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center, Mainz, Germany, 2 Max Planck Graduate Center, Mainz, Germany, 3 Department of Radiology, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 4 Department for Medical Engineering, University of Applied Sciences Upper Austria, Linz, Austria, 5 Department of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, Wrzburg, Germany

Because of long measurement times and the absence of motion during image acquisition, ex-vivo DWI is capable of achieving significantly higher spatial and angular resolutions compared to routine in-vivo imaging. With smaller voxel volumes however, SNR becomes the limiting factor for increasing the spatial resolution. The purpose of this study was to explore these limits in ex-vivo DWI and tractography by maximizing SNR. With a 60 channel coil array optimized for post mortem human brain specimen, a fast segmented 3D EPI acquisition and powerful 300 mT/m gradients, an isotropic resolution of 350m was achieved.

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