Abstract #2849
Comparison of Diffusional Kurtosis Imaging (DKI) and Diffusion Spectrum Imaging (DSI) for White Matter Fiber Tractography
G. Russell Glenn 1 , Jens H. Jensen 2 , Yi-Ping Chao 3 , Chu-Yu Lee 2 , Joseph A. Helpern 4 , and Li-Wei Kuo 5
1
Neurosciences & Center for Biomedical
Imaging, Medical Univesity of South Carolina,
Charleston, SC, United States,
2
Radiology
& Center for Biomedical Imaging, Medical Univesity of
South Carolina, SC, United States,
3
Computer
Science and Information Engineering, Chang Gung
University, Taoyuan, Taiwan,
4
Radiology,
Neurosciences, & Center for Biomedical Imaging, Medical
Univesity of South Carolina, SC, United States,
5
Institute
of Biomedical Engineering and Nanomedicine, National
Health Research Institutes, Miaoli County, Taiwan
This study compares the diffusion orientation
distribution function (dODF) approximations from
diffusional kurtosis imaging (DKI) and diffusion tensor
imaging (DTI) to the dODF reconstructions from diffusion
spectrum imaging (DSI). The DKI approximation of the
dODF can resolve intra-voxel white matter (WM) fiber
crossings for WM fiber tractography (FT) with comparable
angular accuracy to DSI, which improves upon DTI based
WM fiber tractography (FT). With lower scanning
requirements, DKI may be more suitable for clinical
applications than DSI. DKI-based WM FT and associated
quantitative indices may help improve our understanding
of neural connectivity in normal and pathological
states.
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