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Abstract #2858

The structural connectivity basis for supporting functional connectivity in mice

Joanes Grandjean 1 , Zsfia Prhle 2 , and Markus Rudin 1,3

1 Institute for Biomedical Engineering, ETH and University Zurich, Zurich, Switzerland, 2 Department of Physics, ETH Zurich, Zurich, Zurich, Switzerland, 3 Institute of Pharmacology and Toxicology, University Zurich, Zurich, Switzerland

Resting-state fMRI networks are generally organized with a bilateral structure in humans and rodents. Yet, a number of these networks are not supported by direct synaptic connections. This is the case for the caudate-putamen, which is part of the dorsal striatum network in mice. An intermediately region is assumed to relay the information between the two regions; however, such a region is not apparent on the functional connectivity maps. We first compared DTI based tractography in mice with injection-based tractography available from the Allen institute database. We then used probabilistic tracking to identify the fibers involved between each functional network.

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