Abstract #2858
The structural connectivity basis for supporting functional connectivity in mice
Joanes Grandjean 1 , Zsfia Prhle 2 , and Markus Rudin 1,3
1
Institute for Biomedical Engineering, ETH
and University Zurich, Zurich, Switzerland,
2
Department
of Physics, ETH Zurich, Zurich, Zurich, Switzerland,
3
Institute
of Pharmacology and Toxicology, University Zurich,
Zurich, Switzerland
Resting-state fMRI networks are generally organized with
a bilateral structure in humans and rodents. Yet, a
number of these networks are not supported by direct
synaptic connections. This is the case for the
caudate-putamen, which is part of the dorsal striatum
network in mice. An intermediately region is assumed to
relay the information between the two regions; however,
such a region is not apparent on the functional
connectivity maps. We first compared DTI based
tractography in mice with injection-based tractography
available from the Allen institute database. We then
used probabilistic tracking to identify the fibers
involved between each functional network.
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