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Abstract #2861

Combination of super-resolution reconstruction diffusion tensor imaging and track density imaging reveals song control system connectivity in zebra finches

Gwendolyn Van Steenkiste 1 , Julie Hamaide 2 , Ben Jeurissen 1 , Dirk H.J. Poot 3,4 , Johan Van Audekerke 2 , Jan Sijbers 1 , and Marleen Verhoye 2

1 iMinds-Vision Lab, University of Antwerp, Antwerp (Wilrijk), Antwerp, Belgium, 2 Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium, 3 BIGR (Medical informatics and Radiology), Erasmus Medical Center Rotterdam, Rotterdam, Netherlands, 4 Imaging Science and Technology, Delft University of Technology, Delft, Netherlands

Histology does not allow quantitative investigation of structural connectivity on a whole-brain level, in contrast to MRI techniques such as Diffusion Tensor Imaging (DTI). Recently, an in vivo DTI study revealed a novel sexual dimorphism in the zebra finch brain. In order to achieve a precise understanding of the anatomical substrate underlying the observed difference, we propose to use super-resolution DTI (SR-DTI) and track density imaging (TDI). We show that by combining SR-DTI and TDI, a clear anatomical contrast of song control system connectivity as well as a clear delineation of its different components can be realized.

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