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Abstract #2903

Influence of blood flow on intracranial water fluctuation: a phantom study

Shota Ishida 1 , Tosiaki Miyati 1 , Naoki Ohno 1 , Tomohiro Chigusa 2 , Hikari Usui 3 , Masaaki Hattori 4 , Yuki Hiramatsu 4 , Satoshi Kobayashi 5 , and Toshifumi Gabata 5

1 Division of Health sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, 2 Okazaki City Hospital, Okazaki, Aichi, Japan, 3 Yokohama City University Hospital, Yokohama, Kanagawa, Japan, 4 School of Health sciences, College of Medical, Pharmaceutical and Health sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, 5 Department of Radiology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan

To clarify relations and mechanisms of perfusion and water fluctuation, we assessed the influence of blood flow on ADC change in cardiac cycle (delta-ADC) using original cranial MRI-phantom. With use of low b-values, both maximum ADC and minimum ADC during the pulsation period increased with the simulated total cerebral blood flow. However, with high b-values, minimum ADC did not increase with the simulated total cerebral blood flow. Therefore, water fluctuation was predominant with high b-values. Delta-ADC in combination with high b-values makes it possible to minimize the direct effect of blood flow.

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