Meeting Banner
Abstract #2909

Using Continuous Time Random Walk Diffusion to Quantify the Progression of Huntingtons Disease

Allen Q. Ye 1 , Rodolfo Gatto 1 , Luis Colon-Perez 2 , Thomas Mareci 2 , Gerardo Morfini 1 , and Richard Magin 1

1 University of Illinois at Chicago, Chicago, IL, United States, 2 University of Florida, Gainesville, FL, United States

By using continuous time random walk (CTRW) assumptions for diffusion, we have increased sensitivity to micro-architectural heterogeneity and tortuosity through fractional order parameters α and β. We explore the utility of α to distinguish brain tissue alterations in R6/2 mice, a well-characterized Huntingtons disease (HD) model. To this end, we imaged 21 day and 60 day post-natal mice and found changes in α in the corpus callosum. Additional microscopy and histology gives us clues as to the reason behind the change in α. This work is a step toward using fractional order modeling to stage progression of HD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here