Abstract #2909
Using Continuous Time Random Walk Diffusion to Quantify the Progression of Huntingtons Disease
Allen Q. Ye 1 , Rodolfo Gatto 1 , Luis Colon-Perez 2 , Thomas Mareci 2 , Gerardo Morfini 1 , and Richard Magin 1
1
University of Illinois at Chicago, Chicago,
IL, United States,
2
University
of Florida, Gainesville, FL, United States
By using continuous time random walk (CTRW) assumptions
for diffusion, we have increased sensitivity to
micro-architectural heterogeneity and tortuosity through
fractional order parameters α and β. We explore the
utility of α to distinguish brain tissue alterations in
R6/2 mice, a well-characterized Huntingtons disease
(HD) model. To this end, we imaged 21 day and 60 day
post-natal mice and found changes in α in the corpus
callosum. Additional microscopy and histology gives us
clues as to the reason behind the change in α. This work
is a step toward using fractional order modeling to
stage progression of HD.
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