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Abstract #2947

Comparison of diffusion MRI protocols for the microstructural characterization of the spinal cord on the healthy mouse and on a murine model of amyotrophic lateral sclerosis

Matteo Figini 1 , Alessandro Scotti 1 , Stefania Marcuzzo 2 , Silvia Bonanno 2 , Pia Bernasconi 2 , Victoria Moreno Manzano 3 , Jos Manuel Garcia Verdugo 4 , Renato Mantegazza 2 , Ileana Zucca 5 , and Maria Grazia Bruzzone 6

1 Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Milan, Italy, 2 Neurology IV - Neuromuscular Diseases and Neuroimmunology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, 3 Neuronal and Tissue Regeneration laboratory, Centro de Investigacin Prncipe Felipe, Valencia, Spain, 4 Unidad de Neurobiologa comparada, Universidad de Valencia, Valencia, Spain, 5 Scientific Direction, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy, 6 Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy

In this work three diffusion MRI protocol for the study of the mouse spinal cord were compared. They are different both in the number of directions of the diffusion gradients and in the diffusion weightings (b-values). The comparison was based on the variability of the estimated diffusion parameters in both GM and WM and on the detection of microstructural alterations, highlighted by electron microscopy, in a murine model of amyotrophic lateral sclerosis. The overall best-performing protocol was the one with an intermediate number of diffusion directions (12) and a relatively high b-value (b=1200 s/mm 2 ).

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