Abstract #2947
Comparison of diffusion MRI protocols for the microstructural characterization of the spinal cord on the healthy mouse and on a murine model of amyotrophic lateral sclerosis
Matteo Figini 1 , Alessandro Scotti 1 , Stefania Marcuzzo 2 , Silvia Bonanno 2 , Pia Bernasconi 2 , Victoria Moreno Manzano 3 , Jos Manuel Garcia Verdugo 4 , Renato Mantegazza 2 , Ileana Zucca 5 , and Maria Grazia Bruzzone 6
1
Scientific Direction, Fondazione IRCCS
Istituto Neurologico "Carlo Besta", Milan, Milan, Italy,
2
Neurology
IV - Neuromuscular Diseases and Neuroimmunology Unit,
Fondazione IRCCS Istituto Neurologico "Carlo Besta",
Milan, Italy,
3
Neuronal
and Tissue Regeneration laboratory, Centro de
Investigacin Prncipe Felipe, Valencia, Spain,
4
Unidad
de Neurobiologa comparada, Universidad de Valencia,
Valencia, Spain,
5
Scientific
Direction, Fondazione IRCCS Istituto Neurologico "Carlo
Besta", Milan, Italy,
6
Neuroradiology
Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta",
Milan, Italy
In this work three diffusion MRI protocol for the study
of the mouse spinal cord were compared. They are
different both in the number of directions of the
diffusion gradients and in the diffusion weightings
(b-values). The comparison was based on the variability
of the estimated diffusion parameters in both GM and WM
and on the detection of microstructural alterations,
highlighted by electron microscopy, in a murine model of
amyotrophic lateral sclerosis. The overall
best-performing protocol was the one with an
intermediate number of diffusion directions (12) and a
relatively high b-value (b=1200 s/mm
2
).
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