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Abstract #2995

Mesh-based fMRI-driven-tractography for automated analysis of non-parcellateable brains with pathology

Lee Bremner Reid 1,2 , Kerstin Pannek 3 , Roslyn Boyd 2 , and Stephen Rose 1

1 e-Health Research Centre, CSIRO, Brisbane, Queensland, Australia, 2 Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Queensland, Australia, 3 Department of Computing, Imperial College London, London, United Kingdom

A novel mesh-based fMRI protocol was developed to seed and constrain diffusion tractography. This method was used to investigate the integrity of corticospinal tracts in 13 subjects with unilateral cerebral palsy for whom cortical parcellation with Freesurfer was difficult or impossible. Corticospinal tracts were seeded from fMRI hand-tapping tasks. A correlation was suggested between motor ability and the integrity the tracts defined by this method for the impaired hand, but not unimpaired hand. This method allows diffusion analysis of subjects with pathologies that normally would prevent automated analysis, in a manner which avoids blurring of fMRI activation across sulci.

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