Abstract #2995
Mesh-based fMRI-driven-tractography for automated analysis of non-parcellateable brains with pathology
Lee Bremner Reid 1,2 , Kerstin Pannek 3 , Roslyn Boyd 2 , and Stephen Rose 1
1
e-Health Research Centre, CSIRO, Brisbane,
Queensland, Australia,
2
Queensland
Cerebral Palsy and Rehabilitation Research Centre,
University of Queensland, Queensland, Australia,
3
Department
of Computing, Imperial College London, London, United
Kingdom
A novel mesh-based fMRI protocol was developed to seed
and constrain diffusion tractography. This method was
used to investigate the integrity of corticospinal
tracts in 13 subjects with unilateral cerebral palsy for
whom cortical parcellation with Freesurfer was difficult
or impossible. Corticospinal tracts were seeded from
fMRI hand-tapping tasks. A correlation was suggested
between motor ability and the integrity the tracts
defined by this method for the impaired hand, but not
unimpaired hand. This method allows diffusion analysis
of subjects with pathologies that normally would prevent
automated analysis, in a manner which avoids blurring of
fMRI activation across sulci.
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