Abstract #3000
Longitudinal study of cuprizone-induced white matter degeneration and recovery using diffusion White Matter Tract Integrity Metrics (WMTI).
Ileana O. Jelescu 1,2 , Magdalena Zurek 1 , Kerryanne Winters 1,2 , Jelle Veraart 1,2 , Anjali Rajaratnam 1,2 , Timothy M. Shepherd 1,2 , Dmitry S. Novikov 1,2 , Sungheon G. Kim 1,2 , and Els Fieremans 1,2
1
Center for Biomedical Imaging, Dept. of
Radiology, NYU Langone Medical Center, New York, New
York, United States,
2
Center
for Advanced Imaging Innovation and Research, Dept. of
Radiology, NYU Langone Medical Center, New York, New
York, United States
In this 18-week longitudinal study, we quantified
in
vivo
changes
in both conventional MRI (MTR, T
2
, radial
diffusivity) metrics and White Matter Tract Integrity (WMTI)
parameters (derived from diffusion kurtosis imaging)
during cuprizone-induced WM degeneration and subsequent
recovery, in the splenium of the mouse corpus callosum.
All relevant MRI metrics were affected by the cuprizone
treatment and, with the exception of MTR, partially
recovered after treatment ended. WMTI seems to
disentangle between effects of acute and prolonged
exposure to cuprizone, via the different rates of
changes in axonal water fraction and extra-axonal radial
diffusivity. Histological validation is underway.
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