Advanced Diffusion Methods Proved More Robust Assessments of Microstructure than Standard DTI in Complex Human Brain Tissue

Mono-exponential single tensor based diffusion tensor imaging, multi-tensor based generalized q-ball imaging (GQI), and non-mono exponential based diffusion kurtosis imaging (DKI) were performed in ex vivo human frontal cortex at 11.7T with high spatial resolution. Test-retest based analysis showed that GQI and DKI have superior reproducibility than conventional FA suggesting better reliability for assessments of tissue pathology. Furthermore, unlike anisotropy measurements, kurtosis analysis did not show low signal in crossing fiber regions. Thus, in assessing complex white matter for pathology, kurtosis measurements may avoid some of the false positives to which anisotropy-based measurements are susceptible.

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