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Abstract #3012

Whole Body diffusion-weighted MRI: Normal lymph node distribution, volume and apparent diffusion coefficient (ADC) in healthy volunteers

Raphael Shih Zhu Yiin 1 , Giuliano Scattoli 1 , Dow-Mu Koh 1 , David J Collins 2 , Martin O Leach 2 , and Matthew D Blackledge 2

1 Department of Radiology, The Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2 CR-UK and EPSRC Cancer Imaging Centre, Sutton, Surrey, United Kingdom

Whole body diffusion weight imaging (WB-DWI) is being used to evaluate nodal disease in lymphoma and metastatic nodal disease. However, there is an overlap in the MR diffusion properties of malignant and non-malignant lymph nodes. An improved understanding of the DWI characteristics of normal lymph nodes would inform disease assessment. Our study established the whole body distribution of normal lymph nodes and showed the mean ADC value for the nodes to be similar to other published studies. We also defined the full ADC histogram characteristics of normal lymph nodes, which may inform future disease assessment when compared with diseased states.

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