Potential effect of varying background B 0 gradients on diffusion measurements: an in silico study

Here we investigate the ability of double polarity stimulated-echo (STE) and magic-ratio stimulated-echo (MAGSTE) sequences in counteracting susceptibility-induced-background-gradients (Gint).In order to clarify if they compensate Gint effects on DW-NMR signal, numerical simulations were performed.Our results demonstrate that: 1) double polarity STE and MAGSTE fully compensate only for Gint constant and equal during preparation and read interval; 2) only MAGSTE fully compensates for Gint varying in time in a piecewise constant manner; 3) neither double polarity STE nor MAGSTE can compensate for random and uncorrelated Gint variations in space and time, which is the most common condition in heterogeneous living tissues.

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