Abstract #3053
Dynamic Contrast-Enhanced MRI model parameters from different regions within the vascular wall of carotid plaques: comparison with histology
Raf H.M. van Hoof 1,2 , Evelien Hermeling 1,2 , Nicky J.A. Wijnen 1 , Floris H.B.M. Schreuder 1,3 , Martine T.B. Truijman 1,3 , Stefan A. Voo 2,4 , Jack P.M. Cleutjens 2,5 , Judith C. Sluimer 2,5 , Sylvia Heeneman 2,5 , Robert J. van Oostenbrugge 2,3 , Jan-Willem H. Daemen 6 , Mat J.A.P. Daemen 7 , Joachim E. Wildberger 1,2 , and M. Eline Kooi 1,2
1
Radiology, Maastricht University Medical
Center, Maastricht, Netherlands,
2
Cardiovascular
Research Institute Maastricht (CARIM), Maastricht
University, Maastricht, Netherlands,
3
Neurology,
Maastricht University Medical Center, Maastricht,
Netherlands,
4
Nuclear
Medicine, Maastricht University Medical Center,
Maastricht, Netherlands,
5
Pathology,
Maastricht University Medical Center, Maastricht,
Netherlands,
6
Surgery,
Maastricht University Medical Center, Maastricht,
Netherlands,
7
Pathology,
Academic Medical Center, Amsterdam, Netherlands
Pharmacokinetic quantification of the microvasculature
from DCE-MRI in carotid plaques is of great interest.
Currently, various studies focused on different regions
of the vascular wall. In our study, DCE-MRI was
performed and CEA specimens were collected. MRI data was
quantified using the Patlak model and CD31
immunohistochemistry was performed on CEA specimens for
quantification of endothelial microvasculature. Results
showed strongest correlation between adventitial K
trans
and
histology, coinciding with smaller parameter estimation
uncertainties. This indicates that adventitial K
trans
may
be a better measure for plaque microvasculature compared
to other vascular regions.
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