Meeting Banner
Abstract #3055

Concentrating and clearing mechanism of the kidney revealed by QSM at ultra-short TE

Luke Xie 1 , Nian Wang 2 , Chunlei Liu 1,2 , and G. Allan Johnson 1

1 Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, United States, 2 Brain Imaging Analysis Center, Duke University Medical Center, Durham, North Carolina, United States

Ultrashort echo time (UTE) based DCE-MRI alleviates T 2 * blooming artifacts caused by high contrast agent concentrations. However, we showed here that even at 20-μs TE, we still see a significant signal drop off in the kidney. To overcome this limitation, we applied quantitative susceptibility mapping (QSM) to directly quantify the contrast agent concentration. The resulting positive susceptibility enhancement confirmed the very high concentration of the agent. The temporal dynamics revealed the extraordinary mechanism of the kidney to concentrate and clear the agent. UTE-QSM can complement magnitude UTE and offer a powerful tool to study renal physiology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here