Abstract #3055
Concentrating and clearing mechanism of the kidney revealed by QSM at ultra-short TE
Luke Xie 1 , Nian Wang 2 , Chunlei Liu 1,2 , and G. Allan Johnson 1
1
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, North Carolina,
United States,
2
Brain
Imaging Analysis Center, Duke University Medical Center,
Durham, North Carolina, United States
Ultrashort echo time (UTE) based DCE-MRI alleviates T
2
*
blooming artifacts caused by high contrast agent
concentrations. However, we showed here that even at
20-μs TE, we still see a significant signal drop off in
the kidney. To overcome this limitation, we applied
quantitative susceptibility mapping (QSM) to directly
quantify the contrast agent concentration. The resulting
positive susceptibility enhancement confirmed the very
high concentration of the agent. The temporal dynamics
revealed the extraordinary mechanism of the kidney to
concentrate and clear the agent. UTE-QSM can complement
magnitude UTE and offer a powerful tool to study renal
physiology.
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