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Abstract #3081

Dynamic Brain PET/MR using TOF Reconstruction

Mohammad Mehdi Khalighi 1 , Gaspar Delso 2 , Sri-Harsha Maramraju 3 , Michel Tohme 3 , Gary Glover 4 , and Greg Zaharchuk 4

1 Applied Science Lab, GE Healthcare, Menlo Park, CA, United States, 2 Applied Science Lab, GE Healthcare, Zurich, Switzerland, 3 PET/MR Engineering, GE Healthcare, Waukesha, WI, United States, 4 Radiology Dep., Stanford University, Stanford, CA, United States

In a functional PET/MR study, temporal resolution of PET images is lower than that of MR due to SNR limitation. Time-of-flight (TOF) reconstruction can be used to increase PET images SNR and therefore increase the temporal resolution. Five patients were scanned on an investigational simultaneous TOF-enabled PET/MR scanner and PET images were reconstructed with and without TOF. TOF reconstruction showed an SNR improvement of 5-45% (2510%) compared to non-TOF reconstruction. With this additional SNR gain, frame durations as short as 30s were possible while preserving reasonable image quality. Such short frames may be used to increase the temporal resolution of dynamic brain studies using simultaneous PET/MR imaging.

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