Dynamic Brain PET/MR using TOF Reconstruction
Mohammad Mehdi Khalighi 1 , Gaspar Delso 2 , Sri-Harsha Maramraju 3 , Michel Tohme 3 , Gary Glover 4 , and Greg Zaharchuk 4
Applied Science Lab, GE Healthcare, Menlo
Park, CA, United States,
Science Lab, GE Healthcare, Zurich, Switzerland,
Engineering, GE Healthcare, Waukesha, WI, United States,
Dep., Stanford University, Stanford, CA, United States
In a functional PET/MR study, temporal resolution of PET
images is lower than that of MR due to SNR limitation.
Time-of-flight (TOF) reconstruction can be used to
increase PET images SNR and therefore increase the
temporal resolution. Five patients were scanned on an
investigational simultaneous TOF-enabled PET/MR scanner
and PET images were reconstructed with and without TOF.
TOF reconstruction showed an SNR improvement of 5-45%
(2510%) compared to non-TOF reconstruction. With this
additional SNR gain, frame durations as short as 30s
were possible while preserving reasonable image quality.
Such short frames may be used to increase the temporal
resolution of dynamic brain studies using simultaneous
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