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Abstract #3140

Simultaneous in vivo 1 H/ 23 Na-imaging of superficial lymph nodes using 7 Tesla-MRI

Martin T. Freitag 1 , Nadia Benkhedah 2 , Pedram Yazdanbakhsh 3 , Titus Lanz 3 , Moritz Berger 2 , Mathies Breithaupt 2 , Jessica Hassel 4 , Heinz-Peter Schlemmer 1 , Mark E Ladd 2 , and Armin M. Nagel 2

1 Department of Radiology, German Cancer Research Center, Heidelberg, Baden-Wuerttemberg, Germany, 2 Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Baden-Wuerttemberg, Germany, 3 Rapid Biomedical, Rimpar, Bayern, Germany, 4 Department of Dermatology, National Center for Tumor Diseases, Heidelberg, Baden-Wuerttemberg, Germany

There is substantial interest to develop diagnostic procedures for lymph node (LN) staging that feature a high spatial resolution combined with functional imaging techniques because conventional tomographic methods are limited to correctly assess the nodal involvement. 23Na-imaging could be a novel approach for the characterization of often hypervascularized lymph node metastases because sodium is accumulated in malignant cells and blood vessels. By using a double-resonant 1H/23Na-Coil, 5 patients with pathological LNs were examined at 7 Tesla. Here, the first in vivo images of human lymph nodes are demonstrated using simultaneous 1H/23Na-imaging where pathological LNs revealed a higher relative sodium signal.

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