Abstract #3142

Measuring the Rate of Phosphocreatine Recovery in Human Skeletal Muscle after Exercise by Localized 1H MRS without Water Suppression at 7T

Jimin Ren ^1,2 , Baolian Yang ³ , A. Dean Sherry ^1,4 , and Craig R. Malloy ^1,5

¹ Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, ² Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States, ³ Philips Healthcare, Cleveland, Ohio, United States, ⁴ Department of Chemistry, University of Texas at Dallas, Richardson, Texas, United States, ⁵ VA North Texas Health Care System, Dallas, Texas, United States

There has been great interest in measuring ATP synthesis in skeletal muscle in vivo. Conventional methods are 31P NMR-based, either by measuring Pi right arrow

-ATP exchange rate using magnetization transfer, or by measuring the rate of phosphocreatine (PCr) recovery after exercise. This work, based on an early assignment of 1H signal at 3.9 ppm to the methylene of PCr, explores the feasibility of measuring the rate of PCr recovery in exercised muscle using localized 1H MRS without water suppression at 7T. Consistent rate constants were obtained between 1H and 31P MRS by interleaved scans conducted during the same exercise period.

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