Multi-Slice gagCEST Sequence for Whole-Joint gagCEST mapping: Application to Articular Cartilage in the Ankle

Chemical exchange saturation transfer (CEST) is promising new sensitivity enhancement mechanism that detects GAG content (GagCEST), an important marker for early diagnosis of osteoarthritis (OA) and potential treatment monitoring. One of the key concerns of current gagCEST imaging techniques is long imaging times, which often limits acquisition to a single slice and thus may not fully describe the cartilage variation. In this work, we demonstrated the feasibility of multi-slice gagCEST mapping of articular cartilage. Further work to decrease scan time will help advance the clinical utility of gagCEST imaging of articular cartilage.

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