Abstract #3153
Diffusion-sensitized Ophthalmic MRI Free of Geometric Distortion in Patients with Intraocular Masses
Katharina Paul 1 , Andreas Graessl 1 , Jan Rieger 1,2 , Darius Lysiak 1,2 , Till Huelnhagen 1 , Lukas Winter 1 , Robin Heidemann 3 , Tobias Lindner 4 , Stefan Hadlich 5 , Annette Zimpfer 6 , Andreas Pohlmann 1 , Paul-Christian Krueger 5 , Soenke Langner 5 , Oliver Stachs 4,7 , and Thoralf Niendorf 1,8
1
Max-Delbrueck Centre for Molecular Medicine,
Berlin Ultrahigh Field Facility (B.U.F.F.), Berlin,
Berlin, Germany,
2
MRI.TOOLS
GmbH, Berlin, Germany,
3
Siemens Healthcare
Sector, Erlangen, Germany,
4
University
Medicine Rostock, Pre-clinical Imaging Research Group,
Rostock, Germany,
5
University
of Greifswald, Institute for Diagnotic Radiology and
Neuroradiology, Greifswald, Germany,
6
University
Medicine Rostock, Institute of Pathology, Rostock,
Germany,
7
University
Medicine Rostock, Department of Ophthalmology, Rostock,
Germany,
8
Experimental
and Clinical Research Center, a joint cooperation
between the Charit Medical Faculty and the
Max-Delbrueck-Center, Berlin, Germany
Diffusion-weighted imaging (DWI) of the eye and orbit is
an emerging MRI application to provide guidance during
diagnostic assessment and treatment of ophthalmological
diseases. This study employs a RARE based
diffusion-sensitized technique that provides images of
the eye and orbit free of geometric distortion. A small
patient cohort (n=6) is investigated including patients
with uveal melanoma and/or retinal detachment. In one
exemplary case the eye was enucleated as part of the
therapy and ex vivo MR microscopy as well as histology
were conducted. The obtained results underscore the
value of ophthalmic DWI which adds profound clinical
value versus conventional anatomic imaging.
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