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Abstract #3153

Diffusion-sensitized Ophthalmic MRI Free of Geometric Distortion in Patients with Intraocular Masses

Katharina Paul 1 , Andreas Graessl 1 , Jan Rieger 1,2 , Darius Lysiak 1,2 , Till Huelnhagen 1 , Lukas Winter 1 , Robin Heidemann 3 , Tobias Lindner 4 , Stefan Hadlich 5 , Annette Zimpfer 6 , Andreas Pohlmann 1 , Paul-Christian Krueger 5 , Soenke Langner 5 , Oliver Stachs 4,7 , and Thoralf Niendorf 1,8

1 Max-Delbrueck Centre for Molecular Medicine, Berlin Ultrahigh Field Facility (B.U.F.F.), Berlin, Berlin, Germany, 2 MRI.TOOLS GmbH, Berlin, Germany, 3 Siemens Healthcare Sector, Erlangen, Germany, 4 University Medicine Rostock, Pre-clinical Imaging Research Group, Rostock, Germany, 5 University of Greifswald, Institute for Diagnotic Radiology and Neuroradiology, Greifswald, Germany, 6 University Medicine Rostock, Institute of Pathology, Rostock, Germany, 7 University Medicine Rostock, Department of Ophthalmology, Rostock, Germany, 8 Experimental and Clinical Research Center, a joint cooperation between the Charit Medical Faculty and the Max-Delbrueck-Center, Berlin, Germany

Diffusion-weighted imaging (DWI) of the eye and orbit is an emerging MRI application to provide guidance during diagnostic assessment and treatment of ophthalmological diseases. This study employs a RARE based diffusion-sensitized technique that provides images of the eye and orbit free of geometric distortion. A small patient cohort (n=6) is investigated including patients with uveal melanoma and/or retinal detachment. In one exemplary case the eye was enucleated as part of the therapy and ex vivo MR microscopy as well as histology were conducted. The obtained results underscore the value of ophthalmic DWI which adds profound clinical value versus conventional anatomic imaging.

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